Dr. Ronan Kavanagh

Learning from Keith Richards’ fingers

In rheumatology, Uncategorized on September 5, 2011 at 10:08 am

Anyone who’s been reading  Keith Richard’s excellent autobiography will be impressed how he has survived many years of rock and roll, drugs, booze and complicated women. Those with more than a passing interest in rheumatology might have noticed that Keith’s fingers may be aging slightly less well than the rest of him.

These pictures, taken by Francesco Carrozini  makes it obvious to this rheumatologist, that Keith has well established osteoarthritis (OA) of his fingers. 

Most of us who live long enough will get OA in some shape or form and it is by far the commonest form of arthritis.

The particular type of OA that causes the swelling in the distal finger joints is known as ‘nodal OA’  - so called after the hard and bony ‘node’ like swelling it causes in affected joints. Nodal OA can be very painful at the outset (as the bony swellings enlarge) but it is not uncommon for the pain to ease up a bit once the joint stiffens up and no longer moves properly. Its easy though to see how OA of the fingers could cause significant problems for any player.

Anyone who’s even tried to learn a few basic guitar chords will realize how much force and dexterity are required in the fingers of the fret hand to play an F barre chord – simultaneously firmly holding and index finger across all six strings and at the same time getting the middle ring and little fingers to hold three other strings.

A rheumatologist attempting an F chord

Don't try this at home folks

All guitarists (soloists in particular) need a high degree of dexterity to allow their fingers to move quickly around the fretboard with precision and considerable strength. And that’s just the left hand! In addition to the difficulties caused by pain and stiffness of the joints, the enlarged bony nodes can get in the way and make unwanted contact with guitar strings.

Although there has been some speculation in the media that his playing may have contributed to the development of his arthritis, there’s no evidence that playing any instrument wears joints out quickly. Musicians get arthritis, just like the rest of us.

Playing related pain is very common in guitarists though and occurs in between 70% and 80% of them.  Most problems relate to the fret hand and wrist (i.e. the left for most players), low back and neck. Guitarists also suffer from shoulder impingement, tennis elbow, wrist tendonitis, carpal tunnel syndrome, finger tenosynovitis / trigger finger and non specific forearm pain. The symptoms relate primarily to the postures adopted playing the guitar, supporting a heavy instrument, moving heavy amplifiers and equipment, long hours of practicing without breaks, increasing practice time to quickly after a lay-off and lack of aerobic fitness. Stress, sleep disturbance and depression will also influence how these performers experience pain and how they present.

Over the years Keith Richards has also made changes to his playing technique which might have made it easier for him to perform as he gets older. In the late 60′s he started using a form of guitar tuning called ‘open tuning’ (which allows a more economical use of the fretboard compared to standard tuning) and started using a 5 string guitar (a standard guitar has 6 strings). On describing this adaptation, he says;  ’there’s a million places you don’t have to put your fingers. The notes are there already’.

Keith Richards’ continued ability to perform in one the most  hardworking bands in the world is likely to relate to far more than changing his guitar tuning or to his legendary physical constitution. For Keith Richards and for most musicians, giving up music is simply not an option. His observations about the addictive qualities of music and performing give us an insight into the addictive qualities of creating and performing music;  ’a far bigger drug than smack. I could kick smack. I couldn’t kick music. One note leads to another, and then you never know quite what’s going to come next, and you don’t want to. It’s like walking on a beautiful tightrope.’

Health care providers encountering musicians need to be as persistent and as creative as the people we’re caring for in finding solutions to keep them playing. Remember that losing the ability to play music is for many musicians, akin to losing part of themselves.

PS. It has of course occurred to me that by drawing attention to Keith Richards in this way, that I might offend him in some way. Bearing in mind his propensity to throw knives at people who have upset him in the past, I include a link to the Keith Richards Merchandise site to take the edge off his ire. His autobiography, Life, is excellent too.

Arthritis with normal blood tests? Why not..

In Arthritis and Rheumatism, Dr. Ronan Kavanagh, Osteoarthritis, rheumatoid arthritis, rheumatology, Uncategorized on December 20, 2011 at 7:04 am

To most medical students and patients uninitiated in the science of rheumatology, the diagnostic process whereby rheumatologists assess patients may seem bewildering. When considering any patient who presents with joint pain, there are over 100 types of arthritis to consider, lots of conditions which mimic arthritis, a huge array of blood tests to consider and any amount of expensive imaging tests at our disposal. Sounds complicated? It’s not as hard as it seems. When you take gout and joint infections out of the mix (usually easy to spot if you know what you’re doing), you are really trying to determine if your patient has one of two categories of joint problem; a problem relating to joint degeneration or one relating to inflammation.

Only two types of arthritis to consider. That shouldn’t be too hard to do now should it? Here’s some of blood tests that help us do it;

Inflammation blood tests (ESR, CRP)

The results from these two readily available and relatively inexpensive blood tests are probably the first tests any rheumatologist looks for on a patient are the ESR (‘sed rate’) and CRP. These two complementary blood tests help us differentiate between patients with active inflammatory arthritis (eg rheumatoid, psoriatic, reactive arthritis, undifferentiated inflammatory arthritis, ankylosing spondylitis) and those with degenerative joint problem or with other causes of their pain. Although they can be become elevated in conditions other than arthritis (infections and malignancies for example) I tend look on them as measuring the ‘temperature’ of any inflammatory process. The higher above the normal range they are, the more intense the inflammation present. In certain disease states (eg rheumatoid arthritis), very high levels can help us identify patients at higher risk of damage. The closer to the normal range they are, the less likely a patient it to have an inflammatory process. These tests are also used to help monitor the activity of inflammatory arthritis and its response to treatment (one of the ways we know treatment is working is that the CRP / ESR falls during treatment) These tests are not infallible by any means. For a list of pitfalls in their use see below under specific conditions.

Disease Markers (RF, CCP, ANF/ANA)

Once a doctor suspects a patient has inflammatory arthritis, these disease specific tests are used to determine which type of inflammatory arthritis (or other connective tissue disease) they have. Examples of these tests would be Rheumatoid Factor (RF), CCP antibody and Anti Nuclear antibodies (ANA/ANF).

The majority of rheumatoid arthritis will have a positive rheumatoid factor test (‘seropositive’) or a positive CCP antibody (CCP positive). Rheumatoid factors can also occur in some other conditions (eg SLE, Sjogren’s syndrome) but CCP antibodies are usually only present in patients with rheumatoid arthritis. The presence either of these antibodies can help identify patients who are at greater risk of more severe forms of rheumatoid.

There is also some evidence that these antibodies can be present for many years in people before they develop rheumatoid arthritis so be positive in patients without symptoms. The ANF* is usually positive in SLE but can be positive in patients with rheumatoid arthritis. Confused yet?

*Further discussion of the use of Antinuclear antibodies is beyond the scope of this piece

Osteoarthritis

This is the commonest form or arthritis and a condition where ALL of these blood tests listed above should be normal. That means normal ESR, CRP, RF and CCP antibodies unless there’s another condition present alongside the osteoarthritis.

Rheumatoid arthritis

The ESR or CRP may also be normal in patients newly presenting with rheumatoid arthritis. In a large study of RA patients from Finland and US, between 45-47% of patients had a normal ESR, 44-58% had normal CRP at presentation. BOTH were normal in 33% and 42% of patients**. When a rheumatoid factor test was included, 14-15% of patients had no abnormalities in all 3 tests.

Remember that only 70-80% of patients will have a positive rheumatoid factor or CCP antibody (and one can be positive whether the other is negative so we tend to do both) and even greater percentages of pts will have negative antibodies (‘seronegative arthritis’) early on. Having negative antibodies does not therefore exclude rheumatoid arthritis.

It is also well describedthat inflammation can be visible in the joints using MRI ultrasound scans in patients with known rheumatoid arthritis in the absence of inflammation clinically or on blood tests.

** the reason there’s two percentages mentioned is that they looked a patients in two different countries (Finland and USA)

Psoriatic arthritis

Many patients with psoriatic arthritis (approximtely 50%) will have either normal or near normal ESR and or CRP levels. Patients with Psoriatic arthritis will usually have negative rheumatoid factors and CCP antibodies and Antinuclear factors.

Ankylosing Spondylitis / Undifferentiated spondyloarthritis

Ankylosing Spondylitis is a form of inflammatory arthritis (largely affecting the spine). Whereas abnormal CRP and ESR can be very helpful in making a diagnosis of AS in certain patients with back pain, these tests will only be abnormal in about 50% of patients. The rheumatoid factor, CCP antibodies and ANA should be negative in this group of patients.

Palindromic Rheumatism

Palindromic Rheumatism describes a syndrome where there are recurrent episodes of pain swelling warmth and stiffness of joints. The symptoms can have onset over hours and last days – weeks, before subsiding. However episodes of recurrence form a pattern, with symptom free periods between attacks lasting for weeks to months and some of these patients will go on to develop rheumatoid arthritis. It is not unusual for these patients to have normal inflammatory indices (especially between attacks, when they are well) and approximately 50%will have negative Rheumatoid factor and CCP antibodies.]

Conclusions

Making a diagnosis of inflammatory arthritis in patients is usually straightforward but there are some pitfalls to catch the unwary. Whereas the tests can be unreliable in some settings, with the right history and clinical examination in the hands of an experienced rheumatologist, it is possible to make a diagnosis of inflammatory arthritis and offer effective treatment even where the labs don’t quite fit the picture.

Methotrexate and Rheumatic Diseases. A video blog.

In Arthritis and Rheumatism, rheumatoid arthritis, rheumatology, Uncategorized on February 17, 2012 at 8:27 pm

This is a brief video I have prepared which may be of use to patients who have rheumatoid arthritis or psoriatic arthritis (or other arthritis illnesses) considering taking Methotrexate as an arthritis treatment.

It outlines some of the important side effects of methotrexate but also puts them in perspective based on my many years using the drug as a rheumatologist.

This is my first attempt at providing medical information using youtube.

I’d be interested in what people genuinely think of the information posted.

Is it too detailed?

Isn’t it detailed enough?

Are there other topics you’d like to see covered? Please let me know.

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